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The initial dose is 150mg to be taken daily for six daysincreasing on day seven to 150mg twice daily.

It was approved for release as a stop smoking medicine and was given the name Zyban by manufacturers GSK in 1997.

In the literature it has been shown that medications that inhibit CYP2D6 may lead to reduced concentrations of endoxifen which is the active metabolite of tamoxifenTherefore the use of bupropionwhich is an inhibitor of CYP2D6should whenever possible be avoided during tamoxifen treatmentsee section 4.5

A stop smoking date should be set to take place on this second week of the course.

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