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Older adults may be more sensitive to the side effects of this drugespecially drowsinessconfusionconstipationor trouble urinatingDrowsiness and confusion can increase the risk of falling.

Treatment of overdosage is essentially symptomatic and supportiveOnly in cases of extreme overdosage or individual sensitivity do vital signsincluding respirationpulseblood pressuretemperatureand EKGneed to be monitoredActivated charcoal orally or by lavage may be givenor sodium or magnesium sulfate orally as a catharticAttention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilationDiazepam may be used to control convulsionsAcidosis and electrolyte losses should be correctedNote that any depressant effects of promethazine HClpromethazine hydrochlorideare not reversed by naloxoneAvoid analeptics which may cause convulsionsThe treatment of choice for resulting hypotension is administration of intravenous fluidsaccompanied by repositioning if indicatedIn the event that vasopressors are considered for the management of severe hypotension which does not respond to intravenous fluids and repositioningthe administration of norepinephrine or phenylephrine should be consideredEPINEPHRINE SHOULD NOT BE USEDsince its use in patients with partial adrenergic blockade may further lower the blood pressureExtrapyramidal reactions may be treated with anticholinergic antiparkinsonian agentsdiphenhydramineor barbituratesOxygen may also be administered.

Promethazine hydrochloride tablets may lead to potentially fatal respiratory depression.

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promethazine with codeine oral solution is contraindicated in children younger than 12 years of age and in children younger than 18 years of age following tonsillectomy and or adenoidectomy see contraindications .

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