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Famciclovir is the prodrug of penciclovirIt is an orally administered drug and essentially all is converted to the active antiviral compoundpenciclovirPenciclovir has strong inhibitory effects against herpes simplex virus types 1 and 2as well as varicella zosterTyring and coworkers 252 carried out a study of 454 patients with ophthalmic zoster of the trigeminal nerveIn this study patient were randomized to either oral famciclovir 500 mg three times daily or oral aciclovir 800 mg five times a day for 7 daysThe two drugs appeared to demonstrate similar efficacy and famciclovir was well toleratedBecause the drug is cleared in the kidneydosage must be appropriately reduced for patients with reduced renal functionThere are no well-controlled studies in pregnant womenAlthough testicular toxicity was noted in rodentsstudies in normal males did not show a change in sperm count or motilityUrticariahallucinationsand confusion have been reported by patients taking the drug.
For pregnant womenFamciclovir is a category B pregnancy drugThat means two things:
Probenecid and similar drugsIncreased side effects can include headache or nauseaYour doctor will probably not need to adjust your dosage of famciclovirHoweveryou should watch for side effects.
For people with lactose problemsFamciclovir contains lactoseIf you have certain rare conditions that affect how well your body tolerates lactosetalk to your doctor before taking this drugThese conditions include not tolerating galactose or glucose-galactoseThey also include having severely low lactase levels.
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