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Physicians should consider the risks and benefits when prescribing olanzapine to patients with an established diagnosis of diabetes mellitusor having borderline increased blood glucose levelfasting 100-126 mg/dLnonfasting 140-200 mg/dLPatients taking olanzapine should be monitored regularly for worsening of glucose controlPatients starting treatment with olanzapine should undergo fasting blood glucose testing at the beginning of treatment and periodically during treatmentAny patient treated with atypical antipsychotics should be monitored for symptoms of hyperglycemia including polydipsiapolyuriapolyphagiaand weaknessPatients who develop symptoms of hyperglycemia during treatment with atypical antipsychotics should undergo fasting blood glucose testingIn some caseshyperglycemia has resolved when the atypical antipsychotic was discontinuedhoweversome patients required continuation of anti-diabetic treatment despite discontinuation of the suspect drugsee Patient Counseling Information17.5

When using Zyprexa and fluoxetine in combinationalso refer to the Clinical Studies section of the package insert for Symbyax.

Zyprexa ZYDISolanzapine orally disintegrating tabletscontains phenylalanine0.340.450.67or 0.90 mg per 51015or 20 mg tabletrespectivelysee Description11

If a patient requires antipsychotic drug treatment after recovery from NMSthe potential reintroduction of drug therapy should be carefully consideredThe patient should be carefully monitoredsince recurrences of NMS have been reportedsee Patient Counseling Information17.3

There have been no controlled human pregnancy studies on the effects of ZyprexaThe drug can be transferred via human breast milk and potentially harm a babyThereforetalk to your doctor if you are pregnantplanning to become pregnantor are nursing before you take Zyprexa.

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