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Antidepressants increased the risk of suicidal thinking and behaviorsuicidalityin short-term studies in children and adolescents with depression and other psychiatric disordersAnyone considering the use of bupropion or any other antidepressant in a child or adolescent must balance this risk with the clinical needPatients who are started on therapy should be closely observed for clinical worseningsuicidalityor unusual changes in behavior.

Instruct patients to contact a healthcare professional if neuropsychiatric reactions occur.

InitialUp to 3 mg/kg/day or 150 mg/day PO Titrate to 6 mg/kg/day or 300 mg/daymaximum.

450 mg orally once/day without regard to food This drug an be used in people who have been receiving 300 mg/day of another bupropion formulation for at least 2 weeks and who require a dosage of 450 mg/day People who are currently being treated with other bupropion products at 450 mg/day can be switched to equivalent dose of Forfivo XL once daily.

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