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GoutDo not start allopurinol treatment until an acute attack of gout has completely subsidedas further attacks may be caused by this medicationAcute gout attacks may occur at the start of treatment with allopurinol for people who have not taken the medication beforeIf an acute gout attack develops after starting this medicationcall your doctor.

A few cases of reversible clinical hepatotoxicity have been noted in patients taking Zyloprimand in some patientsasymptomatic rises in serum alkaline phosphatase or serum transaminase have been observedIf anorexiaweight lossor pruritus develop in patients on Zyloprimevaluation of liver function should be part of their diagnostic workupIn patients with pre-existing liver diseaseperiodic liver function tests are recommended during the early stages of therapy.

It should also be noted that Zyloprim is generally better tolerated if taken following mealsA fluid intake sufficient to yield a daily urinary output of at least 2 liters and the maintenance of a neutral orpreferablyslightly alkaline urine are desirable.

Every effort has been made to ensure that the information provided by on this page is accurateup-to-dateand completebut no guarantee is made to that effectDrug information contained herein may be time sensitiveThe information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriateunless specifically indicated otherwiseNeither Everyday Health nor its licensors endorse drugsdiagnose patients or recommend therapyThe drug information above is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement toand not a substitute forthe expertiseskillknowledge and judgment of healthcare practitionersThe absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safeeffective or appropriate for any given patientNeither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information providedThe information contained herein is not intended to cover all possible usesdirectionsprecautionswarningsdrug interactionsallergic reactionsor adverse effectsIf you have any questions about the drugs you are takingcheck with your doctornurse or pharmacist.

Renal failure in association with administration of Zyloprim has been observed among patients with hyperuricemia secondary to neoplastic diseasesConcurrent conditions such as multiple myeloma and congestive myocardial disease were present among those patients whose renal dysfunction increased after Zyloprim was begunRenal failure is also frequently associated with gouty nephropathy and rarely with hypersensitivity reactions associated with ZyloprimAlbuminuria has been observed among patients who developed clinical gout following chronic glomerulonephritis and chronic pyelonephritis.

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